Volume 16

October-December 2024

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Formulation and Evaluation of Clove and Eucalyptus Extracts Loaded Dental Film for Treatment of Periodontal Disease

Mohammadkaif Javed Nadaf, Jameel Ahmed S Mulla

Abstract:
The study focuses on the formulation and evaluation of a novel dental film incorporating clove (Syzygium aromaticum) and eucalyptus (Eucalyptus globulus) extracts, aimed at providing an effective localized therapy for periodontal disease. Periodontal disease, characterized by inflammation and degeneration of the supporting structures of the teeth, remains a significant public health concern, necessitating the development of innovative, targeted treatment modalities. In this research, herbal extracts known for their potent antimicrobial, anti-inflammatory, and analgesic properties were incorporated into a biodegradable film matrix, designed to adhere to periodontal pockets and deliver sustained therapeutic effects. The dental films were prepared using a solvent casting method, with optimal concentrations of clove and eucalyptus extracts and different concentrations and ratios of polymers. The physicochemical properties, including thickness, weight variation, surface pH, percentage moisture loss, percentage moisture absorption and folding endurance, were systematically evaluated. In vitro studies assessed the release profile of active compounds, while antimicrobial efficacy was determined against common periodontal pathogens using disk diffusion method. The results demonstrated that the formulated dental films exhibited desirable mechanical properties, controlled drug release, and significant antimicrobial activity against Staphylococcus aureus. These findings suggest that clove and eucalyptus extract-loaded dental films could serve as an effective, patient-friendly adjunct in the management of periodontal disease, offering localized, sustained therapeutic benefits with minimal side effects.

Keywords: Clove extract, Eucalyptus extract, Polyherbs, Dental film, Periodontal disease, Antibacterial activity.

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