Abstract: 
To improve drug delivery systems and to enhance the solubility and Minimizing side effects.to improve stability, and bioavailability of poorly water-soluble drugs. Polymeric micelles (PM) are revolutionising the field of medicine by improving the delivery of poorly soluble drugs, increasing their effectiveness, and lowering their side effects. This results in better gene therapies, targeted drug delivery, and more effective cancer treatments. To put it simply, PM make treatments more accurate and efficient, revolutionising patient care and personalised medicine. Polymeric micelles are paving the way for a future in which medications are safer, more effective. Polymeric micelles typically have a core-shell structure, with a hydrophobic core and a hydrophilic shell. This configuration allows them to encapsulate hydrophobic drugs within the core, enhancing their solubility and stability. Size: They usually range from 10 to 100 nm in size, which is ideal for drug delivery applications as it allows them to circulate in the bloodstream for extended periods and accumulate in target tissues through the enhanced permeability and retention (EPR) effect. Methods for development of micelles: Direct Dissolution, Precipitation/evaporation, Oil/water emulsion, Thin Film Hydration.

Keywords: Polymeric micelles, Colloid, Amphiphilic, Supramolecule, Nanocarriers.

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