Fast-Acting Oral Disintegrating Film for the Delivery of Teneligliptin Hydrobromide Hydrate
Shrishail M Ghurghure, Attar M Kais Sameer, Sumit S Umbardand
Abstract:
The current research work was aimed at optimizing and developing a fast-acting oral disintegrating film of teneligliptin hydrobromide hydrate so as to control the blood sugar level. Solvent casting was used to create the oral disintegrating film containing teneligliptin hydrobromide hydrate. Using a magnetic stirrer, the polymers necessary to prepare ODF were dissolved in an aqueous solution. Teneligliptin was dissolved in the polymer-containing aqueous solution mentioned above, and the mixture was then stirred with a magnetic stirrer. The previously mentioned polymeric solution was then combined with the remaining ingredients and stirred using a magnetic stirrer. Teneligliptin ODF formulations all showed outstanding folding endurance, suggesting that the formulation is robust enough to tolerate handling and transportation. The findings demonstrate the improved physical and chemical characteristics of the oral disintegrating film formulation, along with its good disintegration. The batch of teneligliptin hydrobromide hydrate ODF TF3 that has been optimized displays a pH of 5.8, an oral disintegration time of 45 S, and good folding endurance. The optimized batch’s medication content was discovered to be 96.3%. Every formulation batch has a moisture content that never varies more than 1.5%. This study’s findings show that teneligliptin’s ODF can be created with the intention of improving therapeutic efficacy, increasing bioavailability, and improving patient compliance. Evaluations of the films’ thickness, weight homogeneity, drug content, folding durability, in-vitro release, and disintegration time revealed that they were satisfactory.
Keywords: Disintegrating property, Insulin secretion, Oral disintegrating film, Teneligliptin hydrobromide hydrate.
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