Volume 10

April-June 2018

Development and characterization ‎of rapidly disintegrating tablets of ‎amlodipine besylate

Shivani D Jadhav, ‎Jameel Ahmed S ‎Mulla ‎

Abstract:
Hypertension is one of the most important causes of premature death worldwide and the problem is growing; in 2025, an estimated 1.56 billion adults will be living with hypertension. Amlodipine besylate is a long acting calcium channel blocker used in the treatment of chronic stable angina, vasospastic angina and hypertension. Recent developments in the technology have prompted scientists to develop Rapidly Disintegrating Tablets (RDTs) with improved patient compliance and convenience. The present study aims to prepare and evaluate amlodipine besylate Rapidly Disintegrating Tablets using superdisintegrants by direct compression method. Amlodipine loaded-RDTs were characterized for weight variation, hardness, thickness, friability, wetting time and disintegration time. In vitro drug release study was performed using United States Pharmacopoeia (USP) II dissolution testing apparatus II (paddle method). The results revealed that Amlodipine loaded-RDTs were successfully formulated with good mouth feel, faster disintegration and better drug release.

Keywords: Amlodipine Besylate, Rapidly Disintegrating Tablets, Superdisintegrants, Disintegration Time, In Vitro Drug Release.