Abstract: 
Glibenclamide is BCS class II drug used in the treatment of NIDDM. It has low aqueous solubility and poor bioavailability. Hence, the aim of this study was to increase the solubility of glibenclamide by developing as solid self-emulsifying delivery system. Self-emulsifying region was determined by ternary phase diagram. The optimized formulation contained glibenclamide (5mg), linseed oil (28.80%), Tween 80: PEG 200 (43.19%), and further solidified by adsorbing it on Aerosil 200 using spray dryer. The formulations were evaluated for percent transmittance, emulsification time, percent drug content, in-vitro dissolution study, globule size and zeta potential. The optimized solid formulations showed 96.02% drug release with droplet size 178 nm and emulsification time of 39.27 sec. Optimized formulations showed more release than pure drug. Characterization of the solid SEDDS revealed no interaction among the drug and excipient. DSC study revealed presence of drug in dissolved state while XRD indicated that the drug was in amorphous state. The solid SEDDS which emulsifies rapidly and had very small droplet size can be a promising approach for delivery of poorly water- soluble drugs having low bioavailability.

Keywords: Glibenclamide, Dissolution Improvement, Solid Self Emulsifying System, Spray Drying.