Volume 11

January-March 2019

Exploration of antioxidant ‎potential of Moringa oleifera L. ‎‎(Sehjana) fruits/pods on high fat ‎diet induced rats

Zafar Javed Khan, ‎Naeem Ahmad ‎Khan, Imrana ‎Naseem, Shahab A ‎A Nami

Abstract:
The objective of the present work is to evaluate the in-vivo antioxidant potential of 50% ethanolic extract of Moringa oleifera against high fat diet induced rats. Animal were treated with plant extract for 30 days, and high fat diet was given to all groups except plain control through, out the study, and alpha tocopherol acetate (Vit, E) was used as standard. Pre-treatment with 22 mg/100 gm of body weight of 50% ethanolic extract of Moringa oleifera improved the Superoxide dismutase, catalase, glutathione, and lipid peroxidation levels significantly as compared to control group. The present studies revealed that Moringa oleifera has significant in-vivo antioxidant activity and can be use to protect tissue from oxidative stress. The result showed that the activities of SOD, catalase, lipid peroxidase, and glutathione, in groups treated with high fat diet declined significantly than that of normal group. 50% ethanolic extract of Moringa oleifera in the dose of 22 mg/100 gm of body weight, has improved the SOD, catalase, glutathione, and lipid peroxidation levels significantly, as compared to the alpha tocopherol (Vit,E). Based on this study we conclude that 50% ethanolic extract of Moringa oleifera possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress.

Keywords: Moringa oleifera, Alpha Tocopherol, Superoxide Dismutase, Antioxidant Activity.