Abstract: 
Cancer immunotherapy is an ever growing approach in cancer treatment. Its’ capability to reactivate immunity against cancer, reducing cancer immune evasion, long term metastasis and recurrence further exemplify the potential to revolutionize cancer treatment. Currently available cancer immunotherapies especially cell-based immunotherapy suffer from several setbacks including the loss of HLA-1 molecules, immunosuppresive microenvironment and release of immunosuppresive molecules, all which may compromise their therapeutic effects. Recent advancement in biomaterials might present a solution to these problems. In a cancer immunotherapeutical perspective, many studies have reported the use of biomaterials in scaffolds, delivery systems, immunomodulatory adjuvants and immune cell engineering. Generally, the use of biomaterials increases specificity and decreases side effects. In this article, we provide an overview of the current perspectives of biomaterials application in cancer immunotherapy, its advantages and setbacks, and the future consideration for the use among other modalities in cancer immunotherapy.

Keywords: Biomaterials, Cancer immunotherapy, Bioscaffolds, 3D Cancer Model.