Abstract:
In the event of chronic illnesses, fast-dissolving drug delivery systems have been created as an alternative to traditional dosage forms as an oral mode of drug delivery. Fast dissolving films are now favoured over traditional tablets and capsules for disguising the taste of bitter medications and increasing patient compliance. In this study, montelukast sodium-loaded fast dissolving oral films were made using HPMC K-100 and the solvent casting method. Disintegration time, thickness, tensile strength, percent elongation, folding endurance, moisture content, surface pH, content uniformity, swelling index, FTIR Spectroscopy, Differential Scanning Calorimetry, and an in-vitro dissolution investigation were all used to describe the prepared films. The chemical structure of montelukast sodium was preserved in the formulation, according to FTIR analysis. At the end of 5 minutes, the drug release was found to be between 90.75 and 99.14 percent.

Keywords: Rapidly Dissolving Film, Montelukast Sodium, Solvent Casting Method, Buccal Film.