Volume 2

July-September 2010

Formulation and dissolution studies of solid dispersions of nifedipine

K Nagarajan, M Gopal Rao, Satyajit Dutta, R Pavithra, G Swetha

Nifedipine is a water insoluble antianginal drug and its dissolution rate from solid dispersion was affected largely by the carrier concentration. The common solvent evaporation method and melting fusion method were used for the preparation of solid dispersion in different ratios (9:1, 3:1, 1:1, 1:3, 1:9) using polyethyleneglycol (PEG 4000) to enhance the solubility of drugs. The interaction between drug and carrier were characterized by TLC and IR spectroscopic studies. The Rf value of prepared dispersion was similar to that of the pure drug (0.18) in UV 254 nm light. No extra spots were detected which indicated that there was no interaction between the drug and carrier. In addition, the IR result of the prepared dispersions showed no interactions between the drug and carrier. Hence the prepared solid dispersions improved the dissolution characteristics of Nifedipine as evidenced from the reported results.

Keywords: Nifedipine, Polyethyleneglycol, Antianginal, Tolbutamide.