Abstract:
The aim of our study was to design and evaluate Amlodipine transdermal patches using polymers such as hydroxypropyl methylcellulose. Matrix type transdermal patches containing Amlodipine were prepared by solvent casting method by using polymer like hydroxypropyl methylcellulose (1%, 1.5%, 2% and 2.5%) and a total of eight formulations were prepared. Plasticizers used were propylene glycol and dibutylpthalate. The transdermal patches were evaluated for their physicochemical properties like folding endurance, thickness, percentage moisture loss, percentage moisture absorption, drug content and water vapour transmission rate. The diffusion studies were performed by using franz diffusion cell. Formulation H7 (2% hydroxypropyl methylcellulose with Dibutylphthlate) as plasticizers showed a maximum release of  99% in 24 hours. Out of these eight formulation of hydroxypropyl methylcellulose, 2% hydroxypropyl methylcellulose (H7) was optimized since they produced a sustained and a complete release over a period of 24 hours. Thus the knowledge on the use of chitosan to control drug release in transdermal delivery systems might be applicable to other transdermal drug delivery system as well.

Keywords: Transdermal, Hydroxylpropyl Methylcellulose, Amlodipine.