Abstract:

Captopril loaded maltodextrin based proniosome were prepared by slurry method with different surfactant to carrier ratio. The proniosome formulation was evaluated for FT-IR study and Scanning Electron Microscopy. The niosomal dispersion as further evaluated for entrapment efficiency, invitro release study, kinetic data analysis, stability study. The result from SEM analysis has smooth surface of proniosome. The formulation F6 which showed higher entrapment efficiency of 97.26% and invitro cumulative drug release of 102.26% at the end of 12 hrs. was found to be best among the all 9 formulations. Release was best explained by the First order kinetics. Kinetic analysis showed that the drug release follows Fickian release. Proniosome formulation has showed appropriate stability for 45 days by storing the formulations at different conditions. Captopril provides effective treatment for hypertension and congestive heart failure. However clinical use requires the daily dose of 37.5-75mg to be taken at three times a day. Development of a prolonged action dosage form for captopril will bring many benefits. The development of oral controlled or sustained captopril formulations has been a challenge for a long period of time.

Keywords: Captopril, Proniosomes, Maltodextrin.