Abstract: 
Diacerein is a new anti-inflammatory analgesic and antipyretic drug developed from especially for the treatment of osteoarthritis. The main objective of the study was formulated and evaluated controlled release Diacerein microspheres using egg albumin. Controlled release Diacerein microspheres were prepared by chemical cross-linking method using natural polymer as a egg albumin in different ratio. The Physicochemical compatibility study of drug and polymer was studied by FT-IR spectroscopy. Prepared microspheres evaluated for morphological analysis, entrapment efficiency, drug content, in vitro drug release studies and in vitro anti-inflammatory activity study. Among the prepared formulation containing F5 containing microspheres were found to be best formulation which showed the higher drug release, good entrapment efficiency, extent in vitro drug release and satisfactory anti-inflammatory activity.

Keywords: DCN-Diacerein, OA-Osteoarthritis Egg Albumin, Chemical Cross-Linking Method, HPMC, In Vitro Anti-Inflammatory Activity.