Abstract:
The oral route remains the most preferred for the general population. This system will provide maximum therapeutic efficacy, increased bioavailability and maximum stability by reducing the frequency of dosage. The present work aims to formulate and evaluate fast dissolving oral films of domperidone using HPMC K100 and HPMC E15 as film forming agents by solvent casting method. The prepared films were characterized for weight variation, thickness, tensile strength, folding endurance, surface pH, in vitro disintegration time and mouth dissolving time. Polymer ratio and concentration of superdisintegrants played important role in disintegration and mouth dissolving time. In vitro drug release profile exhibited that formulation with higher concentration of superdisintegrants dissolves the oral films faster than the others.

Keywords: Fast Dissolving Oral Film, Domperidone, FTIR, DSC, Mouth Dissolving Time.