Abstract: 
The present work aimed at preparing films of amlodipine with the reason of developing a dosage from for a very fast onset of action, which is beneficial in managing servere conditions of hypertension, aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water. Amlodipine is a calcium channel blocker that dilates (widens) blood vessles, improves blood flow hence used to treat chest pain (angina) and other conditions caused by coronary artery disease. The films were prepared by a solvent casting method with polymers like hydroxypropyl methylcellulose (HPMC), PVP, PVA and HPC, superdisintegrants SSG. Compatibility study between drug and physical mixture was performed by FT-IR. The films were characterized for various physiochemical properties such as, physical appearance, surface texture, weight uniformity, thickness, drug content, Percentage elongation, moisture content, in vitro study and stability study etc. Compatibility study showed no any kind of interaction between ingredients used. It was observed that concentration of polymer showed effects on physical parameter and dissolution time of formulation. A marked increase in the disintegration time was exhibited by fast-dissolving film containing low concentration of polymers when compared with other films. Fast dissolving films of amlodepine can be considered suitable for clinical use in the treatment of heart disease and other conditions of coronary artery disease, where a quicker onset of action for a dosage form is desirable along with the convenience of administration.

Keywords: Amlodipine Besylate, Fast Dissolving Film, Physical Charcterization, Disintegration Study, In Vitro Release Profile.