Abstract:
Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitations like first-pass metabolism, psychiatric patients, bed ridden and uncooperative patients. Glimepiride is a second generation sulfonylurea of oral hypoglycaemic drug that stimulates the ß-cells of the pancreases to secrete insulin. The mouth dissolving tablets were prepared by direct compression technique. The drug- excipient compatibility studies were performed by Fourier Transform Infrared spectroscopy (FTIR). Physicochemical characteristics and In-vitro drug dissolution tests were performed. The In-vitro drug release pattern and the dissolution data was treated with mathematical modeling accelerated stability studies were also carried out to the optimized formulation (F-6). The FTIR studies revealed that drugs were compatible with the Superdisintegrants used. The optimized formulations were found to have good physicochemical and In-vitro release properties. The In-vitro dissolution data was perfectly fitting to zero order and the release of drug from the formulation followed Higuchi’s release. The accelerated stability studies revealed that the tablets retain their characteristics even after stressed storage conditions. ‎

Keywords: Glimepiride, Fast Dissolving Tablets, Superdisintegrants, Direct Compression.