Abstract:
Periodontal diseases are recognized as the major public health problem throughout the world. Periodontal diseases, including gingivitis and periodontitis, are serious infections that, left untreated, can lead to tooth loss. A novel periodontal film for the treatment of periodontitis was developed in the present work, for local delivery of Norfloxacin against infecting microorganisms in the periodontal pocket. Calibration curves for Norfloxacin was developed in pH 6.6 phosphate buffers at 273.8 nm respectively. FT-IR studies revealed that no interaction between the selected drug and polymers. Periodontal films were prepared by solvent casting technique using ethyl cellulose and other co-polymers in different solvents with dibutyl phthalate and polyethylene glycol as plasticizers. The formulated periodontal films were evaluated for their folding endurance, percent moisture loss, surface pH, viscosity, thickness, uniformity of weight, tensile strength, content uniformity, in-vitro release and Stability studies. Data of In-vitro release from the formulated periodontal films were fit to different equations and kinetic models to explain release kinetics. Kinetic models used were zero and first-order equations and Higuchi models. Formulation F6 released 99.74% of drug at the end of tenth day was considered as the optimized formulations F6. There were no significant changes in formulation F6 during stability study. Periodontal films might be a potential formulation for the treatment of periodontitis.

Keywords: Norfloxacin, Periodontitis, Controlled Release, Periodontal Film, Gingivitis.