Abstract:
The main objective of this study was to formulate and evaluate the orodispersible tablets of Clopidogrel bisulfate with natural, synthetic Superdisintegrants. Clopidogrel bisulfate an antiplatelet drug used is an inhibitor of platelet activation and decreases subsequent platelet aggregation. Clopidogrel bisulfate has its oral bioavailability (50) and biological half life (5-10 hrs). In the present study an attempt was made to formulate oral disintegrating tablets of Clopidogrel bisulfate with a view to achieve a better disintegration and dissolution rate and further improving the bioavailability of the drug. Orodispersible tablets were prepared using various concentrations (10%, 15%) of super disintegrants like Moringa oleifera, Plantago Ovata, and co-processed excipients like 1:1 ratios of Moringa oleifera along with by direct compression method. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the precompression parameters and the values were within prescribed limits and indicated good free flowing properties. The tablets prepared by direct compression method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in-vitro dissolution. Amongst all the prepared formulations, F4 and F7 which comprised of Moringa oleifera and Plantago Ovata 1:1 ratio at 10% concentration prepared by direct compression method was found to the best formulation as it exhibited satisfactory physical parameters.

Keywords: Orodispersible Tablet, Clopidogrel Bisulphate, Superdisintegrants, Direct Compression, Moringa oleifera, Plantago Ovata.