Abstract:
The present study involves preparation and characterization of extended release matrix pellets by using Lornoxicam as a model drug for prolong release of drug for extended period of time after predetermined lag time for the chronotherapy of rheumatoid arthritis. The pellets were prepared by the Extrusion and Spheronization method using as release retarding polymers like xanthan gum, xyloglucan and is combination with PVP K-30 and MCC PH-101 as pelletization aid. Matrix Pellets had characterized by flow properties, differential scanning calorimetry, scanning electron microscopy, particle size, circularity, roundness, aspect ratio, crushing strength, percent drug content, percent production yield, percent friability and in vitro drug release. The effects of various formulation variables on the size and drug release were also investigated. In this study, the feasibility and influence of incorporation of natural gums by itself and in combination with other gums on the ability to form spherical pellets by extrusion spheronization techniques. Matrix pellets containing 30% xanthan gum, 30% of xyloglucan and 30% combination of XG: Xg which showed sustained release of lornoxicam for15 h.

Keywords: Multiple Unit, Matrix Pellets, Lornoxicam, Natural Gums, In-Vitro Drug Release.