Abstract:
Etodolac has been used for treatment of Rheumatoid Arthritis(RA) and Osteoarthritis. It is a BCS class II drug i.e. low solubility & high permeability and major absorption site is stomach region. It shows dissolution rate-dependent bioavailability. This work was carried out to improve the dissolution rate and controlled release of drug so it could retain in the stomach for longer period of time delivering to the site of action i.e. stomach. Aim of the present work is to prepare and characterization of Gastro Retentive Hallow Micro Balloons of etodolac by using two acid resistant polymers such as Eudragit RS 100 & ethyl cellulose with different ratio, Eudragit RS 100 is water insoluble over the entire range of pH it swells in stomach in swollen state it is permeable to water and dissolved actives. In this study solvent diffusion /evaporation technique was used to prepare a gastro retentive hallow micro balloons for etodolac and influence of several factors on various physical characteristics, including particle size, buoyancy, drug entrapment /loading, in vitro dissolution drug release characters are investigated.

Keywords: Ethodolac, RA, Osteoarthritis, BCS II, Eudragit RS 100, Buoyancy, Drug Entrapment.