Volume 1

October-December 2009

Influence of process variables on particle size of solid lipid nanoparticles

J S Mulla, I M Khazi

Solid lipid nanoparticles (SLNs) were prepared via microemulsion method. SLNs formulation consists of lipid (glyceryl monostearate (GMS), stearic acid (SA) and trilurin (TLN)), stabilizers (soy lecithin and tween 80) and water. Influence of type of lipid, concentration of lipid, individual and in combination of stabilizers and homogenizer speed on particle size were studied intensively. Particle sizes were determined by laser scattering using a Malvern Mastersizer 2000 particle size analyzer. A higher concentration of lipid was found to rapidly increase the size of nanoparticles. In contrast, an increase in stirring rate and concentration of stabilizer agent were found to reduce moderately the size of the nanoparticles.

Keywords: Solid Lipid Nanoparticles, Microemulsion, Particle Size, Glyceryl Monostearate, Stearic Acid, Trilurin.