Abstract: 
It is required to appropriately translate the drug dosage from one animal species to another when a new drug is developed. The animal dose should not be extrapolated to a human equivalent dose (HED) by a simple conversion based on body weight as was reported. For the more appropriate conversion of drug doses from animal studies to human studies body surface area (BSA) normalization method is more accurate. BSA correlates well across several mammalian species with several parameters of biology including oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function.

Keywords: Body Weight, HED, BSA, Parameters.