Abstract:
Rheumatoid arthritis include inflammation of  joints and classified as autoimmune disorder. The complete Freund’s Adjuvant induce Arthritis is the most widely used animal model of arthritis. Spironolactone have immunomodulatory, antioxidant and anti-inflammatory properties, so might be it can use as an antiarthritic drug. The present work is to investigate the antiarthritic effect of spironolactone on CFA induced arthritis. The female rats were divided into five group containing six animal in each group and CFA induce arthritic rat were treated with spironolactone (56 mg/kg and 28 mg/kg), methotrexate and vehicle till 21^st day. The results of treatment is evaluate by paw volume, body weight, ESR, arthritis index, TNF-α and IL-6. The female rats were immunized with CFA to induce rheumatoid arthritis. Spironolactone shows significant changes in all the parameters. The level of cytokines is reduced by oral administration of spironolactone. The results are nearly related as compare to methotrexate. Improvement in paw volume, body weight, ESR, arthritic score, TNF-α and IL-6 indicates that spironolactone might be used as the novel treatment of arthritis.

Keywords: Rheumatoid Arthritis, CFA, Spironolactone, Methotrexate.