Abstract: 
Drug actions can be improved by developing new drug delivery systems; one such Liquisolid compact of gliclazide was prepared with the intension of improving the dissolution properties of gliclazide. Polyethylene glycol (PEG), Propylene glycol (PG) and mixture of both were used as non volatile liquid. The dissolution studies of the liquisolid compacts were performed in vitro, and the results obtained showed that the dissolution rate of gliclazide was considerably improved when formulated in liquisolid compact with PG and PEG as compared to original drug, and the increased dissolution rate favorable for further oral absorption. In the comparative pharmacokinetic study with gliclazide suspension, a reference drug product, liquisolid system (LS1-A3) showed improved bioavailability with higher C_max and faster T_max. We conclude that liquisolid system (LS1-A3) is a good candidate for the development of oral solid dosage forms.

Keywords: Liquisolid Compact, Gliclazide, Dissolution Rate.