Volume 14

January-March 2022

Nanosuspension: A novel approach

M K Andhale, R D Wagh, H D Mahajan​

Abstract: 
Nanosuspension is an attractive and promising alternative to solve these problems. Nanosuspension consists of the poorly water-soluble drug without any matrix material suspended in dispersion. Preparation of Nanosuspension is simple and applicable to all drugs which are water insoluble. A Nanosuspension not only solves the problems of poor solubility and bioavailability, but also alters the pharmacokinetics of drug and thus improves drug safety and therapeutic efficacy. Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort. Preparation of Nanosuspension is simple and applicable to all drugs which are aqueous insoluble. Nanosuspensions are prepared by using wet mill, high pressure homogenizer, emulsion solvent evaporation, melt emulsification method and super critical fluid techniques. Nanosuspension can be prepared by using stabilizers, organic solvents and other additives such as buffers, salts, polyols, and cryoprotectant. Nanosuspensions can be delivered by oral, parenteral, pulmonary and ocular routes. Nanosuspensions can also be used for targeted drug delivery when incorporated in the ocular inserts and mucoadhesive hydrogels.

Keywords: Dissolution, Solubility, Solubility Enhancement, Surfactant.