Volume 13

January-March 2021​

Novel drug delivery formulations of herbal bioactive molecules

Hariom Singh, Ranjana Choudhari

Abstract: 
The various novel drug delivery approaches for the therapeutic molecule are widely seeking attention in the field of biomedical science. However, the accuracy and efficacy of the drug is a major issue of concern. However, the herbal drug therapy has been in use from thousands of the years or from the ancient time to treat the patients. Hence the use of pure active chemical of the herbal isolate can be an alternative approach which may resolve the issue. We utilized multiple databases, PubMed (Medline), EMBASE and Google Scholar for literature search. The scientists and researchers are trying to apply the current advanced drug delivery concept on the herbal medicines to reduce the unwanted pharmacological and physiochemical side effects of the therapeutic molecules. There are various novel drug delivery systems which are being used for the delivery of the herbal bioactive molecules, such as the polymeric micelle, injectable hydrogel, Nano gel, microsphere, polymeric nanoparticles, Nanoemulsions, liposomes, Nanocapsules, phytosomes, dendrimer, transferosomes, and ethosomes. These formulations have a great number of advantages like the enhancement of drug solubility, bioavailability, dose reduction, drug distribution, drug stability, sustained delivery, protection from the drug degradation and minimization of the adverse effects and toxicity. The present review highlights the existing research and development for the herbal bioactive molecules and summarizes their preparation methodologies, characterization techniques, route of administration, and type of active ingredients, size distribution, pharmacological activity and applications of novel herbal formulations.

Keywords: Herbal Bioactive Molecules, Drug Delivery, Bioavailability, Formulations, Vesicular Drug Delivery System.