Abstract: 
Now a day, nasal drug delivery has occupied an important place in the field of drug delivery technology. A range of medicaments can be successfully delivered at the site of action using drug delivery devices. A successful nasal drug delivery device seems to deliver medication efficiently, necessarily non-invasive, helps in rapid onset of action, patient friendly for self administration and should exhibit minimal side effects. Since constructing an efficient drug delivery device, capable of achieving sufficient local, systemic or brain distribution of drug is a challenge, usually requires a robust and innovative technology. Fortunately, the nose offers easy access to a large mucosal surface, well suited for delivery of many therapeutics including proteins and peptides. Present review deals with such novel nasal drug delivery devices, more specifically, OptiNose, ViaNase, Direct Haler, MAD-nasal ^TM mucosal atomizer, which have proven their proficiency in delivering medications. The clinical status of the therapeutics administered by these devices along with their regulatory requirements has also been extended.

Keywords: Nasal Drug Delivery, Drug Delivery Devices, OptiNose, ViaNase, Direct Haler , MAD-nasal ^TM Mucosal Atomizer.