Abstract: 
Pellets are agglomerates of granules or core powders and blend of active pharmaceutical ingredients with pharmaceutical excipients. Pellets size ranges from size 0.5 to size 1.5 mm. The process of pellet formation known as pelletization. In relation to pharmaceuticals, pellets offer high degree of flexibility in design and development of oral dosage form. This review outlines theory of pellet formation, mechanism of drug release from multi-particulates, and factors affecting on multiparticulate system. Various pelletization techniques used for manufacturing of pellets includes agglomeration, direct pelletization, compression, extrusion–spheronization, layering technique, droplet formation, freeze pelletization, hot-melt extrusion technology (HME) and Pellet coating include fluidized bed processor. Also give idea about Characterization and application of pelletization techniques.

Keywords: Pellets, Mutiparticulate, Spheronizer, Extrusion.