Abstract: 
Cocrystals as defined by the FDA are, “Solids that are crystalline materials composed of two or more molecules in the same crystal lattice”. Co-crystallization is a new approach of enhancement of solubility, stability, bioavailability and other physicochemical properties. Cocrystal can be made via the solvent evaporation method, grinding method, slurry process, cooling co-crystallization and anti-solvent method although each of these techniques has limitations under specific circumstances. The most novel techniques for creating crystals these are spray drying, supercritical fluid technology, microwave assisted, ultrasound assisted solution and, most recently, laser irradiation.

Keywords: Pharmaceutical Co-crystal, Methods of Preparation, Physico-chemical Properties, Applications.