Volume 15

July-September 2023

Review Articles

A R Kharat, S K Malode, B Y Wankhede

The use of conventional oral drug delivery systems is convoluted by limited gastric residence time for the drugs having a narrow absorption window. Rapid GI transit can prevent the complete release of the drug in the absorption zone and it reduces the efficacy of the provided dose. Since the majority of the drugs are absorbed in the stomach or in the upper part of the small intestine. To conquer these limitations various advanced drug delivery systems have been developed to increase the gastric residence of the drugs in the upper part of GIT and to maximize the oral absorption of drugs. One such novel approach is the gastro-retentive drug delivery system. In general, this study could help researchers to explore new approaches for creating safe and effective gastroretentive systems in order to make them more widely used in clinical practices and the treatment of diseases. This review paper highlights several factors, including modern innovative technology, that are helpful in the development of gastroretentive drug delivery systems.

Keywords: Gastro-Retentive Drug Delivery System, Novel Technology, Gastroscopy, Quality By Design, Migrating Myoelectric Cycle.

Hrituja N Tibile, Kranti D Desai

The medicinal herb Nigella sativa (N. sativa) of the Ranunculaceae family is utilized extensively all over the world. It is widely used in several conventional medical systems, including Unani Tibb, Ayurveda, and Siddha. Folklore has long used seeds and oil in a variety of food and medical systems. Numerous illnesses and disorders have been treated with N. sativa seeds in the past. It is regarded as one of the greatest healing arts in Islamic literature. Its seeds and oil are frequently used to treat a variety of illnesses, such as rheumatoid arthritis, asthma, inflammatory diseases, diabetes, and digestive disorders. This study’s goal was to give an in-depth analysis of the scientific publications that have been published concerning N. sativa.

Keywords: Nigella sativa, Black Seed, Medicinal Plant, Phytoconstitute, Pharmacological Activity.

Ritik Domaji Zilpe, Jameel Ahmed S Mulla

Cocrystals as defined by the FDA are, “Solids that are crystalline materials composed of two or more molecules in the same crystal lattice”. Co-crystallization is a new approach of enhancement of solubility, stability, bioavailability and other physicochemical properties. Cocrystal can be made via the solvent evaporation method, grinding method, slurry process, cooling co-crystallization and anti-solvent method although each of these techniques has limitations under specific circumstances. The most novel techniques for creating crystals these are spray drying, supercritical fluid technology, microwave assisted, ultrasound assisted solution and, most recently, laser irradiation.

Keywords: Pharmaceutical Co-crystal, Methods of Preparation, Physico-chemical Properties, Applications.

Hitendra Mahajan, Dhiraj Sonje

Nanomedicine holds a great role to improve therapeutic strategies against drug delivery as to develop multi-functionality and advanced targeting tactics. Hybrid nanoparticles (HNs) having small particle size, because of small particles it is used in traditional therapies. HNs improving pharmacokinetics and pharmacodynamics characteristics against disease or treatment. HNs circulating in the circulation for an extended period of time to reach targeted spot. Recent years have seen a rise in interest in polymer-based nano-medicines due to their potential to increase the effectiveness of cancer therapeutics. This field includes the use of polymer DNA complexes (Polyplexes), polymer-drug conjugates, lipid polymer type of nanoparticles as hybrid nano-medicines, and polymer micelles bearing hydrophobic drugs. In this review the HNs of lipid and polymer are taken in focus in accordance with benefits and drawbacks of lipid as well as polymer drug targeted delivery and how the combination of lipid and polymer as hybrid nanoparticle is beneficial to achieve desired therapeutic effect in treatment with their types and preparation with some available formulations and drugs.

Keywords: Nanotechnology, Hybrid Nanoparticles, Lipids, Polymers.

Research Articles

Siddhi Maruti Chavan, Jayshree Kishor Sonawane, Snehal Chandrashekhar Jale, Nidhee Vinayak Tendulkar, Ishwari Prakash Narkar, Vaishali Jadhav, Ashish Jain

Curcumin and thymoquinone are well-known phytochemicals. However, these natural bio-actives poor water solubility and restricted penetration impede their effective delivery and potential therapeutic result. This study was carried out to design and characterize a novel solid self-micro emulsifying drug delivery system of class IV drugs by adsorption approach employing Syloid®244 FP as the solid carrier for solubility increase of Curcumin and Thymoquinone. The optimized liquid SMEDDS for Curcumin and Thymoquinone contains 30:15:45 oil Oleic acid, surfactant Tween20, and co-surfactant PEG 400. It demonstrated good self-emulsification performance and a clear appearance. Characterization investigations revealed that solidification using 50% (w/w) Syloid®244 FP in the liquid formulation results in a free-flowing powder with no agglomeration. The liquid and solid SMEDDS formulations created a fine oil-in-water microemulsion with mean globule sizes of 153±7.4 nm respectively. As a phosphate buffer pH 6.8 dissolution environment, the drug synthesized as solid SMEDDS was swiftly and thoroughly dissolved (90%) within 120 minutes, but crude curcumin powder was much less soluble. The Curcumin-Thymoquinone loaded SMEDDS demonstrated strong antibacterial activity against Staphylococcus aureus, antifungal activity against Candida albicans, and moderate antibacterial activity against Escherichia coliin antimicrobial assays. Curcumin-Thymoquinone loaded-SMEDDS formulation in liquid & solid dosage forms were successfully developed with an increased drug loading and dissolution rate, which could be the potential combined delivery system for various anti-bacterial and anti-fungal treatments.

Keywords: Curcumin, Thymoquinone, SMEDDS, Adsorbent, Solubility Improvement, Combined Therapeutic Effects.

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