Abstract: 
Nanomedicine holds a great role to improve therapeutic strategies against drug delivery as to develop multi-functionality and advanced targeting tactics. Hybrid nanoparticles (HNs) having small particle size, because of small particles it is used in traditional therapies. HNs improving pharmacokinetics and pharmacodynamics characteristics against disease or treatment. HNs circulating in the circulation for an extended period of time to reach targeted spot. Recent years have seen a rise in interest in polymer-based nano-medicines due to their potential to increase the effectiveness of cancer therapeutics. This field includes the use of polymer DNA complexes (Polyplexes), polymer-drug conjugates, lipid polymer type of nanoparticles as hybrid nano-medicines, and polymer micelles bearing hydrophobic drugs. In this review the HNs of lipid and polymer are taken in focus in accordance with benefits and drawbacks of lipid as well as polymer drug targeted delivery and how the combination of lipid and polymer as hybrid nanoparticle is beneficial to achieve desired therapeutic effect in treatment with their types and preparation with some available formulations and drugs.

Keywords: Nanotechnology, Hybrid Nanoparticles, Lipids, Polymers.