Volume 15

April-June 2023

Review Articles

Raktimava Das Sarkar, Aritra Ghosh, Aryama Bose, Subhrajit Sarkar

Electrosomes are a type of vesicle that hold promise as a drug delivery system due to their unique properties. Electrosomes can encapsulate a wide range of therapeutic agents, including small molecules, proteins, peptides, and nucleic acids. They can also release drugs in a controlled manner, either by diffusion or in response to an external stimulus such as heat or light. In addition, electrosomes can be administered non-invasively and have the potential to improve drug stability, bioavailability, and cost-effectiveness. Despite these advantages, there are also potential disadvantages to consider, including complexity in production, limited scalability, stability concerns, and ethical considerations. Ongoing research is exploring ways to overcome these limitations and improve the effectiveness and safety of electrosomes as a drug delivery system. Electrosomes represent an exciting area of study for pharmaceutical researchers and scientists, with the potential to address many of the challenges of traditional drug delivery systems. Further research is needed to fully understand the potential of electrosomes and their limitations, but their versatility and controlled release capabilities make them a promising platform for drug delivery and other biomedical applications.

Keywords: Electrosomes, Nanovesicles, Drug Delivery, Pharmaceutical, Novel Drug Therapy.

Anuradha U Bhoi, Samruddhi D Pise, Udaykumar A Bhoi

Topical drug delivery refers to the administration of medications through cutaneous, vaginal, ophthalmic, and rectal channels to any part of the body. Drugs may be administered for systemic or local effects. It is possible to create topical preparations through different physicochemical characteristics like solid, semisolid and liquid. Emulgel is a topical remedy. Prepared using an emulsion as well as gel mixture. Emulgel is regarded as one of the most significant topical delivery systems since it contains both an emulsion and a gel release control system. Emulgels often don’t have any harmful side effects. This novel drug delivery system’s main goal is to use the skin to introduce hydrophobic medications into the bloodstream. Typically, emulsion is mixed with gel basis to create emulgel. In comparison to other topical drug delivery systems, it exhibits improved drug release due to the absence of insoluble excipients and excessive oily bases. Due to non-greasy due to the gel phase’s existence, this encourages good patient compliance. Studies on emulgel indicate that it will be possible to give more topical medications in the future due to its advantages over other methods.

Keywords: Emulgels, Topical Drug Delivery, Emulsion, Gel, Gelling Agent.

Piyusha P Nejdar, Basavaraj S Hunagai, C Mallikarjuna Setty, Gaviraj E N, Chanabasappa V Nagathan

Prior to the invention of conventional antibiotics, medicinal plants were used to treat human illnesses. However, because they are affordable, accessible, and free of the side effects sometimes associated with conventional antibiotics, medicinal herbs continue to be used by people. From the perspectives of pharmacognosy and microbiology, reproducibility has become a problem when screening plants for antibacterial activity.  Although it’s normally not one component but a mixture of metabolites, the beneficial medical effects of plant materials are typically caused by the secondary products present in the plant. Some therapeutic plants have multiple functions, such as targeting microbial proteins and peptides, which are crucial for the creation of natural remedies.

Keywords: Antimicrobial, WHO, Medicinal Plants, Bioactive Compounds, Mechanism.

Research Articles

Snehal Kurhe, Kedar Bavaskar, Pallavi Chavan, Prasad Vidhate, Ashish Jain

Transdermal drug delivery systems are discrete, self-contained dosage forms that release drugs to the bloodstream at a controlled rate through the skin. By incorporating the drug (Febuxostat) into Transfersomal gel using the thin film hydration process with various polymer concentrations, it is possible to increase entrapment effectiveness and drug penetration. As the study mentioned preparation of Transfersomes by using Different ratios of Soya lecithin and Non-ionic surfactant (Span 60 and Tween 20). Transfersomal dispersion then incorporated into gelling agent Carbopol 934 to make Transfersomal Gel. The Drug and excipient study performed by FTIR and revealed that they are compatible with each other. Out of all the batches F4 proved to be optimized batch because of highest entrapment efficiency which was found to be 92.70%. Zeta potential and PDI was -39.7mV and 260.3nm respectively. Optimized Transfersome batch (F4) and Carbopol 934 Gelling agent was used to prepare Transfersomal Gel. The viscosity and spreadability of different concentration of Gelling agent was done. In vitro drug release of F4TG4 was found to be highest release than other three batches. Based on our kinetics study the results revealed that all formulations were best fitted in Zero order release kinetic model. The stability study was performed as per ICH guidelines. Our research indicates that the Transfersomal formulation offered a sustained and longer medication delivery with increased bioavailability and better patient compliance. The transdermal route of the transfersomal formulation may be an effective dose form to lessen the unfavourable side effects of the oral route.

Keywords: Febuxostat, Transfersomes, Franz Diffusion Cell, Carbopol 934, Zero Order Kinetics, Zeta Potential, Gout, Stability Study.

Nilam U Metkari, Sunita S Shinde, Supriya S Kore, Sipora S Gaikwad, Pallavi B Tanwade, Omkar B Tipugade

The present study was aimed to enhance the solubility and dissolution of BCS class II drug, Telmisartan (TEM), by nanoformulation approach. Several attempts were made to develop a nanosuspension by bottom-up and top-down techniques. Bottom-up techniques such as anti-solvent precipitation and emulsification solvent evaporation methods failed to reduce the size of the drug to nanoform by Poloxamer 108 and PVP K-30 at 1500–2000 rpm but resulted in micron-sized particles. However, the high pressure homogenization method has produced nanosuspension with a particle size of 112.6 nm and 0.119 PDI. Formulation and analytical development were carried out by statistical factorial design using the Design Expert software (version 11.0). The prepared nanosuspension was evaluated for particle size, entrapment efficiency, zeta potential and in-vitro dissolution. Zeta potential of optimized formulation was found to be −18.6 m V. Drug content and its release was estimated by the developed and validated in-vitro dissolution method. In vitro drug release studies on the optimized formulation have shown a drug release of 50.63% by the end of 6 h, whereas plain drug suspension has shown only 24.39% release, indicating a 2-fold increase of drug release with nanosuspension. It can be concluded that TEM, when formulated by high pressure homogenization technique as a nanosuspension, leads to enhanced solubility, dissolution, and stability. Thus, nanosuspension is promising approach to improve dissolution and bioavailability (BA) of Telmisartan

Keywords: Telmisartan, Pluronic, Nanosuspension, DoE, High Pressure Homogenization, Bottom-Up Anti-Solvent Precipitation Method.

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