Abstract:
Metabolic disorders are associated with some major health complications like myocardial infarction, stroke, nephropathy, neuropathy, retinopathy etc. Diabetes is one of the major life threatening metabolic disorder. The present study was designed to evaluate the antidiabetic activity of Trewia nudiflora L. and study was carried out on alloxan induced experimental diabetic mice (Swiss albino) for 120 minutes treatment.  Experimental methanol extract of root of T. nudiflora showed ***P<0.001 indicates significant blood sugar lowering activity at 500mg/kg b.w and mild activity was observed at dose 250mg/kg comparing to diabetic control where metformin was used as reference positive standard. Leaves extract of T. nudiflora did not show any antidiabetic activity at both doses 250 and 500mg/kg b.w respectively. The phytochemical screening showed the presence of Glycoside, flavonoid, Tannin and steroid type of compounds. Roots extract possesses anti-diabetic effect which may be mediated through the phytochemical constituents of the plant.

Keywords: Antidiabetic, Alloxan, Blood Glucose, Trewia Nudiflora L.