Preparation and Evaluation of Febuxostat Transfersomal Transdermal Drug Delivery System
Snehal Kurhe, Kedar Bavaskar, Pallavi Chavan, Prasad Vidhate, Ashish Jain
Transdermal drug delivery systems are discrete, self-contained dosage forms that release drugs to the bloodstream at a controlled rate through the skin. By incorporating the drug (Febuxostat) into Transfersomal gel using the thin film hydration process with various polymer concentrations, it is possible to increase entrapment effectiveness and drug penetration. As the study mentioned preparation of Transfersomes by using Different ratios of Soya lecithin and Non-ionic surfactant (Span 60 and Tween 20). Transfersomal dispersion then incorporated into gelling agent Carbopol 934 to make Transfersomal Gel. The Drug and excipient study performed by FTIR and revealed that they are compatible with each other. Out of all the batches F4 proved to be optimized batch because of highest entrapment efficiency which was found to be 92.70%. Zeta potential and PDI was -39.7mV and 260.3nm respectively. Optimized Transfersome batch (F4) and Carbopol 934 Gelling agent was used to prepare Transfersomal Gel. The viscosity and spreadability of different concentration of Gelling agent was done. In vitro drug release of F4TG4 was found to be highest release than other three batches. Based on our kinetics study the results revealed that all formulations were best fitted in Zero order release kinetic model. The stability study was performed as per ICH guidelines. Our research indicates that the Transfersomal formulation offered a sustained and longer medication delivery with increased bioavailability and better patient compliance. The transdermal route of the transfersomal formulation may be an effective dose form to lessen the unfavourable side effects of the oral route.
Keywords: Febuxostat, Transfersomes, Franz Diffusion Cell, Carbopol 934, Zero Order Kinetics, Zeta Potential, Gout, Stability Study.