Abstract:
Telmisartan is member of BCS class II with oral bioavailability of 40% and antagonizes the action of non-peptide amphiphilic AT1 receptor. In present study, the author aimed to modify its dissolution profile by formulating in nano suspension form by using solvent evaporative technique. Various combination of stabilizer and a surfactant are used and their concentrations were optimized for cumulative percentage release, saturation solubility and particle size (nm) by the means of 3² full factorial design. The particle size of the optimized batches were found to be of  335.5 ± 8.45 nm, 554.6 ± 15.11 nm, respectively. The results of in vitro drug release study of optimized batches exhibited significant improvement in the dissolution rate and saturation solubility when compared with marketed formulation.

Keywords: Dissolution Rate, Nanosuspension, Saturation Solubility, Telmisartan, Solvent Evaporative Technique.