Abstract: 
Diabetes is a disease that occurs when your blood sugar or glucose level was not into the normal blood sugar or glucose level. Various drugs uses in the Treatment of Diabetes Type-2 and act by lower your blood sugar in a variety of ways. Sulphonylureas were discovered by Auguste Loubatières as the first pharmacological family of oral anti-diabetic drugs (OADs) is a kind of oral medication that works to regulate blood sugar levels in people with type 2 diabetes by stimulating insulin synthesis in the pancreas, which increases the efficacy of insulin in the body are typically divided into two generations (1^st Generation and 2^nd Generation). Glibenclamide, commonly known as Glyburide, is a kind of 2^nd generation Sulphonylureas used in the treatment of type 2 diabetes mellitus. The creation of a novel formulation including both chemicals provides significant efficiency and compliance benefits, as well as operating as a multi-target medication system. The enhancement of the solublity and formulate Enhanced formulation like Transdermal patches, Inhalers, Misopourous silica.

Keywords: Diabetes, Glibenclamide, Formulation.