Volume 3

July-September 2011

Solid lipid nanoparticles: Methods of preparation

J S Mulla , I M Khazi , Naveen Kumar Sharma , S P Hiremath , V G Jamakandi

Solid lipid nanoparticles (SLN) introduced in 1991 represent an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. The SLN combine the advantages (e.g. physical stability, protection of incorporated labile drugs from degradation, controlled release, excellent tolerability) of other traditional colloidal systems. This review describes the different ways of SLN production such as high pressure homogenization, ultrasonication, solvent emulsification/ evaporation, microemulsion, spray drying and double emulsion method.

Keywords: Solid Lipid Nanoparticles, High Pressure Homogenization, Ultrasonication, Solvent Emulsification/ Evaporation Micro Emulsion, Spray Drying, Double Emulsion.