Volume 2

July-September 2010

Solid lipid nanoparticles: Potential applications

J S Mulla, I M Khazi, V G Jamakandi

In the middle of the 1990s, the attention of different research groups has focused on alternative nanoparticles made from solid lipids by name solid lipid nanoparticles (SLN or lipospheres or nanospheres). The SLN combine the advantages (e.g. physical stability, protection of incorporated labile drugs from degradation, controlled release, excellent tolerability) of other traditional colloidal systems, such as emulsions, liposomes and polymeric microparticles and nanoparticles; while at the same time minimizing the associated problems. SLN formulations for various application routes (parenteral, oral, dermal, ocular, pulmonar, rectal) have been developed and thoroughly characterized in vitro and in vivo. Recently, solid lipid nanoparticles (SLN) have been widely studied as a next-generation delivery system in pharmaceuticals and cosmetics. This paper reviews the applications of lipid based carrier systems, SLN.

Keywords: Solid Lipid Nanoparticles, Administration Routes, Controlled Release, Targeted Drug Delivery.