Abstract:
Niosomes (non-ionic surfactant vesicles) were biodegradable, biocompatible, and non- immunogenic in nature and having flexibility in structure & storage. These are chemically stable, recently many researchers work on niosomes by oral drug delivery to provide better bioavailability to drug. Niosomes provides better encapsulation in biological membrane and maintain stability. Submicron sized vesicle consisting of single and double chain non-ionic surfactant mixtures which was prepared simply by dispersion of surfactants dissolved in aqueous medium or alternatively dissolved surfactant were injected in organic solvent in to an aqu. phase. Drug entrapped values were measured by using flurocent markers like 5-6- Carboxyfluroscein and drug release rate is evaluated in biological media that is (serum & plasma) as a function of surfactant composition and in the presence or absence of cholesterol. Surfactant charge measurement is done by zeta potential as a function of pH, gel electrophoresis and immunoblotting were used to know the compatibility study between biological fluid component and prepared vesicles. It was found that all the vesicle carries negative charge & rapidly bound to the plasma protein which include albumin & imunoglobulin-G that affects the latency of entrapped marker.

Keywords: Niosomes, Non-ionic Surfactant Vesicles, Zeta Potential, Liposomes, Gel Electrophoresis, Immunoblotting, Carboxyfluroscein.