Abstract:
The aim of the present research is to formulate the emulgel of Oxiconazole Nitrate, an antifungal drug for the topical delivery. The formulation was prepared by using carbopol 934, HPMC K4M and xantham gum at different concentration. The formulations were evaluated for compatibility studies, physical appearance, pH, viscosity, spreadability, photomicrography, in-vitro studies, antifungal activity, extrudability and stability studies. The prepared formulations were found to be homogeneous. pH and spreadability was found to in the range of 5.6-6.1 and 19.01- 26.30 respectively. Among all the formulations (F1-F6), formulation F2 containing carbopol 934 and F5 containing Xanthan gum shown highest drug release (88.18 and 92.51%) after 24 hrs. Antifungal activity of the formulations was assessed by comparing with the marketed ZODERM^TME cream. The release studies follow the zero order kinetics. The short term stability studies were conducted for the optimized formulation and it was found to be stable. Hence the oxiconazole emulgel is the promising implement for the antifungal activity.

Keywords: Hydrophobic Drug, Emulgel, Oxiconazole Nitrate, Topical Drug Delivery.