Abstract:
Transdermal drug delivery is optimistic, but challenging system available for accessible as well systemic effect of the drug. Drug entry is followed by intercellular, transcellular or appendageal route. The intention of the present examination was to developed a nanogel with diminish particle size in order to ameliorate the bioavailability of the anti-fungal drug, Fluconazole. The present investigation is an endeavor to deliver the transdermal delivery of Fluconazole nanogel. Nanogel has been the frame having size extending from 100-400 nm. Glycerol and water ratio is 20:80 and co-solvent system is selected for performing Fluconazole nanogel using various polymers and has better permeability coefficient than alcohol: water cosolvent. Gels containing Fluconazole with Eudragit polymer appeared better permeability coefficient. Fluconazole nanogel formulated using carbopol with saturation enrich has shown better flux enrichment in comparison with nanogel formulated using Glycerol and Triethanolamine. Fluconazole nanogel with Eudragit and carpool as gelling agent has better flux enhancement with Triethanolamine.

Keywords: Fluconazole, TDDS, Eudragit S-100, Glycerol, Carbopol-940, Cellophane Membrane.