Abstract: 
Niosomes are nonionic surfactant-based vesicles that are biodegradable, relatively nontoxic, more stable, and less expensive than liposomes. The bilayer structure of niosomes makes them one of the greatest transporters. In aqueous media, nonionic surfactants form a closed bilayer vesicle based on their amphiphilic nature, using energy such as heat or physical agitation to form this structure, with the hydrophobic part remaining away from the aqueous solvent and the hydrophilic part remaining towards the aqueous solvent. The main text of the article provides the overview of the niosomes including the components of the niosomes such as cholesterol and surfactants, their merits and demerits, methods of preparation, and recent advances in application of niosomes with respect to different routes of delivery like including topical, transdermal, oral, and pulmonary, trans mucosal and ocular drug delivery. Niosomes have been intensively explored in recent years for a variety of uses, including topical, transdermal, oral, and pulmonary, trans mucosal and ocular drug delivery. They are simple to prepare and have a lower cost than its analogue system, liposomes, while also having a higher EE. In the disciplines of pharmaceutical and aesthetic sciences, this adaptable drug delivery technology offers a lot of potential.

Keywords: Niosomes, Compositions, Merits, Demerits, Preparation Methods, Encapsulation, Surfactants, Vesicles, Applications.