Abstract: 
Due to the scarcity of tissue donors, scaffold construction and biomaterial selection are critical components of artificial tissue and bone tissue engineering. This study examines the characterisation, applications, manufacturing processes, biomaterials, and scaffold design issues. Scaffolds must include non-hazardous qualities including biocompatibility and biodegradability for human body as well as the mechanical capabilities needed to support body weight and, depending on the kind of tissue, carry out additional functions. To ensure cell viability and proliferation, scaffold structures like porosity, pore size, and pore shape should be tuned. Natural polymers, synthetic polymers, ceramics, and composites are the different categories of biomaterials. This article has covered various modern and traditional fabrication techniques. In order to match the qualities of the scaffold with the target tissue, the field of bone tissue engineering will need to strike a balance between the method of manufacturing and the choice of biomaterial

Keywords: Scaffold, Biomaterials, Fabrication, Applications, Bone Tissue Engineering.