Volume 10

January-March 2018

Dendrimers as a novel approches ‎for drug delivery system: A review

Kulkarni K V, ‎Ghurghure S M

Abstract: 
This review provides brief information concerning with the dendrimer, its properties, its synthesis, characterization and application in drug delivery. Dendrimer consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. The unique architectural design of dendrimers, high degree of branching, multivalency, globular architecture and well defined molecular weight, clearly distinguishes these structures as unique and optimum nanocarriers in medical applications such as drug delivery, gene transfection, tumor therapy, diagnostics, etc. Synthetic approaches lead to a dendritic architecture with properties amenable to modifications of shape, size, polarity, surface properties and internal structure. Nanoparticle drug-delivery systems are the popular ones as are able to increase the selectivity and stability of therapeutic agents. As a result of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications.

Keywords: Dendrimers, Properties, Synthesis, Types, Characterization, Applications, Polyamidoamine (PAMAM) Dendrimer.