Volume 7

July-September 2015

Review Articles

Dhyani Archana, Belwal Pragati, Juyal Divya

Fast-dissolving drug delivery systems have been developed as an alternative to conventional dosage form as an oral means of drug delivery in case of chronic conditions. Now a day’s fast dissolving films are preferred over conventional tablets and capsules for masking the taste of bitter drugs to increase the patient compliance. Fast dissolving films consist of a very thin oral strip which dissolves in less than one minute when placed on the tongue. Dissolvable oral thin films are in the market since past few years in the form of breath strips and are widely accepted by consumers for delivering vitamins, vaccines and other drug products. The various manufacturing techniques for the preparation of films have also been detailed in the review. The present review details most of the patents on such fast dissolving films in recent years. A brief study has been made on various parameters which are used to evaluate such films. In case of chronic disorders these fast dissolving films are better for delivering drugs and obtaining faster therapeutic blood levels and superior in comparison to other oral conventional dosage forms.

Keywords: Fast Dissolving, Films, Plasticizers, Techniques.

Research Articles

Hitendra S Mahajan, Vinayak B Kokate

The aim of the present work was to develop and characterize oral dissolving film of pregelatinized hydroxypropyl pea starch (Lycot RS720®) polymers for oral delivery of tadalafil. ODFs films were prepared by solvent casting technique. Formulations were prepared based on Box-Behnken statistical design with concentrations of Lycot RS720® and glycerin (plasticizer) as independent variables. Two dependent variables considered were tensile strength and drug release. Results revealed that film containing 25% (w/v) of Lycot RS720® and 3% (w/v) glycerin demonstrated more than 90% drug release within 5min. SEM images demonstrated smooth and uniform surface of film suitable for oral mucosa. Thus, this study suggests that pregelatinized hydroxypropyl pea starch can act as a rapid dissolving film forming polymer for oral delivery of a tadalafil.

Keywords: Pregelatinized Hydroxypropyl Pea Starch, Oral Dissolving Films, Polymer, Tadalafil.

Jyoti S Ranmale, Nilima A Thombre, S J Kshirsagar, Archana S Aher

Introduction: Medicated Chewing Gum is considered as vehicle or drug delivery system to administer active principles that can improve health and nutrition. It is a novel drug delivery system containing masticatory gum base with pharmacologically active ingredient and intended to use for local treatment of mouth diseases or systemic absorption through oral mucosa. The buccal route of drug administration also has important advantage of direct access to the general circulation and overcomes the first pass hepatic metabolism. Methods and Materials: The aim of present study was to design and characterise Medicated Chewing Gum for the treatment of bacterial infection using Amoxicillin Trihydrate as model drug. The chewing gums were prepared using Health in Gum grade01(HiG-01) as a directly compressible gum base developed by Cafosa (S.A.U.), Spain. The effect of concentration of (Base) Gum Base, (release modifier) Aerosil, and (antiadherant) talc was studied. Result and discussion: The dissolution study showed that optimum amount of Gum Base shows superior result. Amoxicillin Trihydrate is an antibacterial agent. After oral administration it is rapidly absorbed. Maximum peak plasma concentration is reached after approximately 1 hr this model drug is selected for the study in order to overcome the hepatic first-pass effect and there by possible reduction in the dose. The drug is tasteless so there was no issue with taste masking. Amoxicillin Trihydrate has higher oral bioavailability, less side effects and has short duration of action of about 1.02 hr; these factors make Amoxicillin Trihydrate is suitable candidate for formulation of medicated chewing gum used to treat bacterial infection.

Keywords: Medicated Chewing Gum (MCG), Health in Gum-01, Amoxicillin Trihydrate.

Jaydeep Kothawade, Pankaj Nerkar, Hitendra Mahajan, Pradum Ige

Cefuroxime axetil is a broad-spectrum, β-lactamase stable, second generation cephalosporin antibiotic. Cefuroxime axetil, an orally absorbed pro-drug of cefuroxime is used to treat elderly group of patient with sympathomimetic urinary tract infections. The drug is practically insoluble in water and exhibits slow intrinsic dissolution rate and poor bioavailability. The objective of this work was to enhance the dissolution rate of cefuroxime axetil by converting it into liquisolid compacts. Liquisolid compacts consisted of microcrystalline cellulose (Avicel pH 102) as carrier material, Aerosil 200 as coating material, and propylene glycol as nonvolatile solvent. Solubility studies of cefuroxime axetil in propylene glycol, Tween 80, polyethylene glycol 400 and glycerin were carried out and propylene glycol (11.12±1.06 mg/ml) was selected as a non volatile solvent in which drug is having the highest solubility. The drug concentration was kept constant in all formulations. Optimization was carried out using Box-Behnken design by selecting liquid load factor, amount of nonvolatile solvent, and carrier coating ratio as independent variables; cumulative percentage drug release, hardness, and angle of repose were considered as dependent variable. Any interaction between cefuroxime axetil and the other components were evaluated by FTIR. Dissolution test was carried out at pH 1.2. The results showed that liquisolid compacts demonstrated significantly higher drug release rates than those of directly compressed tablet.

Keywords: Cefuroxime Axetil, Liquisolid Tablet, Avicel 102, Box-Behnken Design, Aerosil 200, Carrier Material, Coating Material.


Yuvraj S Pawara, Ravindra R Patil, Hitendra S Mahajan

The study was aimed extraction of mango powder from mango pulp; The presence of carbohydrate was confirmed by phytochemical analysis. The drugs and extract were found to be compatible as confirmed by IR spectral studies. The mango powder was evaluated for its micromeritic properties viz. bulk density, tap density, angle of repose, Hausners’s ratio, Carr’s index and the results indicated good flow properties. The formulations were prepared using mango pulp powder and other excipient. The prepared granules were free flowing and the compressed tablets showed good friability and hardness. The drug content of all the prepared formulations was ranging from 96.5- 100.0%. This study confirmed that the mango pulp can be used as an effective release retardant and can be successfully used in development commercial products.

Keywords: Flavoring, Diluents, Mangifera Indica and MCC, Mango Pulp Powder.

Short Communications

Priyanka Soni, Vishal Soni, Lajja Patidar, Nikita Rijhwani

Ayurvedic eye drops preparation contains aqueous extracts of different herbs. Ethnobotanical survey shows that plants used in Ayurvedic eye drops formulation are rich source of tannin and tannin like compounds. Tannins are responsible for antimicrobial and antioxidant properties of Ayurvedic eye drops. The present study was designed with the aim to determine the tannin content in 3 different brands of Ayurvedic eye drops, by colorimetric method using Folin-denis reagent. The tannin content of all the three brands was found to be A-825.23, B-656.00 and C-558.49 µg/ml. The results obtained are reproducible with coefficient of variation less than 0.99 %. The present approach can be used as one of the parameters for the standardization of Ayurvedic eye drop preparations.

Keywords: Ayurvedic Eye Drops, Tannins, Folin-denis Reagent, Spectrophotometer.

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